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Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome–like Clinical Presentation in Human Immunodeficiency Virus–infected Children in Malawi

Year: 2019

Type: article

Study design: Case Report

Abstract: We describe 7 human immunodeficiency virus-infected Malawian children with Kaposi sarcoma who met criteria for Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome. Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and severe cytopenias. Plasma analyses were performed in 2 patients, both demonstrating extreme elevations of KSHV viral load and interleukin 6.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciz250

Authors: Nader Kim El-Mallawany, William Kamiyango, Jimmy Villiera, Erin C Peckham-Gregory, Michael E Scheurer, Casey L McAtee, Carl E Allen, Carrie L Kovarik, Dale Frank, Anthony B Eason, Carolina Caro-Vegas, Elizabeth Y Chiao, Gordon E Schutze, Nmazuo W Ozuah, Parth S Mehta, Peter N Kazembe, Dirk P Dittmer

Institutions: Baylor College of Medicine, University of Pennsylvania, University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Michael E. DeBakey VA Medical Center, Texas Children's Hospital

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: United States Agency for International Development, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G2137883186, G2411152879, G3478697556, G4380112734, G757867161, G7776447822, Origin and Lineage of Differentiation of Kaposi's Sarcoma, G9000241706, Viral Oncogenesis, Latency, and Replication, G96349998, G99424851

OpenAlex ID: W2924875274

FWCI: 0.453

Cites: 16

Cited by: 15

Related to: 10