Year: 2019
Type: article
Study design: Observational Study
Abstract: Multiple myeloma (MM) and its precursor condition MGUS are characterized by chromosomal aberrations. Here, we comprehensively characterize the order of occurrence of these complex genomic events underlying MM development using 500 MGUS, and MM samples. We identify hyperdiploid MM (HMM) and non-HMM as genomically distinct entities with different evolution of the copy number alterations. In HMM, gains of 9,15 or 19 are the first and clonal events observed as clonal even at MGUS stage. These events are thus early and may underlie initial transformation of normal plasma cells to MGUS cells. However, CNAs may not be adequate for progression to MM except in 15% of the patients in whom the complex subclonal deletion events are observed in MM but not MGUS. In NHMM, besides the driver translocations, clonal deletion of 13 and 1q gain are early events also observed in MGUS. We combined this information to propose a timeline for copy number alteration.
Source: Blood Cancer Journal
Institutions: Harvard University, Dana-Farber Cancer Institute, Centre National de la Recherche Scientifique, Inserm, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes Université, VA Boston Healthcare System, Institut universitaire du cancer de Toulouse Oncopole, Dana-Farber/Harvard Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,380
OpenAlex ID: W2924887250