Poly- and perfluoroalkyl substances (PFASs): from external exposure to human blood
Year: 2018
Type: dissertation
Study design: Observational Study
Abstract: This thesis contributed to the field of human exposure to environmental pollutants called poly- and perfluoroalkyl substances (PFASs). Daily intakes of PFASs via ingestion, inhalation, and dermal absorption were estimated and compared to the internal doses. Overall, diet contributed most to the daily intake of PFASs, followed by house dust, indoor air, and dermal absorption, but some variations were observed on an individual basis.\n\nSignificant associations between concentrations of PFASs measured in serum, and estimated intakes based on direct and indirect (precursor) exposure were observed. Measured serum concentrations and modelled serum concentrations based on external exposure estimates were in the same order of magnitude. The estimated daily intakes of PFASs in this study were lower than the health-based guidance values.\n\nAlso, in this study, analytical methods have been developed and validated for the determinations of a broad range of PFASs in serum, plasma, whole blood, dried blood spot, and hand wipes. This study underlines the importance of performing studies considering multiple exposure pathways on an individual basis.
Author: Somrutai Poothong
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2924920611