End‐of‐Trial Health Outcomes in Look AHEAD Participants who Elected to have Bariatric Surgery
Year: 2019
Type: article
Abstract: Objective This study examined end‐of‐trial health outcomes in participants in the Action for Health in Diabetes (Look AHEAD) trial who had bariatric surgery during the approximately 10‐year randomized intervention. Methods Data were obtained from the Look AHEAD public access database of 4,901 individuals with type 2 diabetes and overweight/obesity who were assigned to intensive lifestyle intervention (ILI) or a diabetes support and education (DSE) control group. Changes in outcomes in participants who had bariatric surgery were compared with those in participants with BMI ≥ 30 kg/m2 who remained in the ILI and DSE groups. Results A total of 99 DSE and 97 ILI participants had bariatric surgery. At randomization, these 196 participants were significantly younger and more likely to be female and to have higher BMI than the remaining ILI (N = 1,972) and DSE (N = 2,009) participants. At trial’s end, surgically treated participants lost 19.3% of baseline weight, compared with 5.8% and 3.3% for the ILI and DSE groups, respectively, and were more likely to achieve partial or full remission of their diabetes. Conclusions The large, sustained improvements in weight and diabetes observed in this self‐selected sample of surgically treated participants are consistent with results of multiple randomized trials.
Source: Obesity
DOI: 10.1002/oby.22411
Institutions: University of Pennsylvania, Wake Forest University, University of Minnesota, Johns Hopkins University, Johns Hopkins Medicine, University of Pittsburgh, University of Tennessee Health Science Center, Brown University, Miriam Hospital, National Institute of Diabetes and Digestive and Kidney Diseases
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, Centers for Disease Control and Prevention, National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Center on Minority Health and Health Disparities, National Center for Research Resources, Office of Research on Women's Health
Awards: G1149464818, G1153163889, G1561916549, G1681235271, G1902398179, G2115812462, G2247787434, G2279102038, G2456504948, G2519210884, 05/16 Action for Health in Diabetes Extension Study - Research Project, G3144056878, G3237517486, General Clinical Research Center, 14/16 Action for Health in Diabetes Extension Study Research Project, General Clinical Research Center, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, G3728863030, University of Pittsburgh Clinical and Translational Science Institute, Neural response to food stimuli: fMRI changes following cognitive behavioral therapy for binge eating disorder, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, General Clinical Research Center, 04/16 Action for Health in Diabetes Extension Study Research Project, 03/16 Action for Health in Diabetes Extension Study Research Project, G6477361739, 13/16 Action for Health in Diabetes Extension Study Research Project, G7376939847, 15/16 Action for Health in Diabetes Extension Study Research Project, Obesity/Nutrition Research Center, 12/16 Action for Health in Diabetes Extension Study Research Project, 06/16 Action for Health in Diabetes Extension Study Research Project, Diabetes Research Center, Colorado Nutrition Obesity Research Center, G955307958
OpenAlex ID: W2925069552