Effect of Alcohol Skin Cleansing on Vaccination Local Skin Reactions: A Randomized Controlled Trial
Year: 2018
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective: To assess the effectiveness of skin cleansing with alcohol in reducing the incidence of delayed pain post-vaccination, and assess the feasibility of conducting a larger trial. Methods: Participants were randomized to either be cleansed at (swab) or adjacent to (control) the injection site with 70% isopropyl alcohol then let dry before vaccine administration. Parents blinded to the treatment allocation reported local reactions for 15 days post-vaccination using paper diaries and 3 telephone surveys. Results: In 6.5 months, 170 patients were recruited and received 281 vaccine injections. Eighty-one percent of diaries were returned and 94% of parents completed all 3 phone surveys. There was no difference in the incidence of reported delayed pain or any local skin reactions between both groups. Discussion: These findings are the first evidence specifically for vaccination injections demonstrating that cleansing the skin with alcohol may not be needed.
Source: TSpace (University of Toronto)
Author: Horace Wong
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Hospital for Sick Children
OpenAlex ID: W2925109097