Trends in the prevalence of airflow limitation in a general Japanese population: two serial cross-sectional surveys from the Hisayama Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Chronic obstructive airway disease, which is characterised by airflow limitation, is a major burden on public health. Reductions in environmental pollution in the atmosphere and workplace and a decline in the prevalence of smoking over recent decades may have affected the prevalence of airflow limitation in Japan. The present epidemiological study aimed to evaluate trends in the prevalence of airflow limitation and in the influence of risk factors on airflow limitation in a Japanese community. DESIGN: Two serial cross-sectional surveys. SETTING: Data from the Hisayama Study, a population-based prospective study that has been longitudinally conducted since 1961. PARTICIPANTS: A total of 1842 and 3033 residents aged ≥40 years with proper spirometric measurements participated in the 1967 and 2012 surveys, respectively. MAIN OUTCOME MEASURES: Airflow limitation was defined as forced expiratory volume in 1 s/forced vital capacity <70% by spirometry. For each survey, the age-adjusted prevalence of airflow limitation was evaluated by sex. ORs and population attributable fractions of risk factors on the presence of airflow limitation were compared between surveys. RESULTS: The age-standardised prevalence of airflow limitation decreased from 1967 to 2012 in both sexes (from 26.3% to 16.1% in men and from 19.8% to 10.5% in women). Smoking was significantly associated with higher likelihood of airflow limitation in both surveys, although the magnitude of its influence was greater in 2012 than in 1967 (the multivariable-adjusted OR was 1.63 (95% CI 1.19 to 2.24) in 1967 and 2.26 (95% CI 1.72 to 2.99) in 2012; p=0.007 for heterogeneity). Accordingly, the population attributable fraction of smoking on airflow limitation was 33.5% in 2012, which was 1.5-fold higher than that in 1967 (21.1%). CONCLUSIONS: The prevalence of airflow limitation was decreased over 45 years in Japan, but the influence of smoking on airflow limitation increased with time.
Source: BMJ Open
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,839
Awards: G1255986592, G1529877714, G1698328007, G1801308478, G2198203189, Longitudinal association of glycemic biomarkers with diabetic complications in the community, G2464535496, The risk assessment of the development of diabetes mellitus using genetic variants and fatty acid, G270403562, G3178897077, G3372692003, G3516836897, G3689480463, G3741071645, G4060705838, A large-scale survey of tongue microbiota of elderly adults for the development of its maintenance approach, G4166337557, G4366806955, Molecular epidemiology of virulence of microbiome considering host immune response, Prediction of caardiovascular disease by dyslipidemia and chronic kidney disease in a general Japanese population: The Hisayama study, G6093486696, G6107810936, G6224203819, G627898309, G6832303597, G7243531383, Integration of out-of-office blood pressure for investigating comprehensive risk on cardiovascular complications., G7380130029, G7427915865, Longitudinal study on the elucidation of actual state of dementia and its risk/protective factors in Hisayama elderly residents, G7923246015, International comparison study between Japan and Korea aiming at paradigmshift from 8020 to 8028, G8958250955, G8993279099, G931188625, G931252876
OpenAlex ID: W2925129255