Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery
Year: 2017
Type: article
Abstract: Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform's biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.
Source: Scientific Reports
Institutions: Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Wyss Institute for Biologically Inspired Engineering, Massachusetts Institute of Technology, University of Michigan, Massachusetts General Hospital, King Abdulaziz University, Washtenaw Community College, University of California, Los Angeles, University of Victoria, Northeastern University, Konkuk University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: National Science Foundation, American Heart Association, King Abdulaziz University, King Abdulaziz City for Science and Technology, National Institutes of Health, National Plan for Science, Technology and Innovation, National Heart, Lung, and Blood Institute, Office of Naval Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Biomedical Imaging and Bioengineering, National Institute of Dental and Craniofacial Research, Division of Emerging Frontiers in Research and Innovation
Awards: G1924069901, A Microfabrication Platform for Direct Printing Vascularized Functional Tissue Co, G3875323066, G4046635724, Engineering Vascularized Bone Tissues By Microfabrication And Scaffolding, G4227133446, G4458583999, G5648020265, EFRI-BioFLEX: Tissue Engineered Flexible Sensors, Actuators and Electronics for Chronic Wound Management, G5784848077, Engineering bioprintable Cardiac Tissues, Microengineered Osteons for Bone Tissue Engineering, G6987093379, G708482841, 3D combinatorial microenvironments for effective cell based therapy, Microfabricated Vascularized 3D Tissue Engineered Constructs, Microengineered environments for epithelial-mesenchymal interactions (SysCODE 7, MICROFLUIDIC SYSTEM FOR SCREENING STEM CELL MICROENVIRONMENTS, G8324953376, G8343742952, G8446123221, G8938364791, G9000147734, G9000214283
OpenAlex ID: W2750323300