Work

Capillary Microfluidics-integrated Impedance Sensor for Rapid Label-free Antibody Sensing

Year: 2016

Type: conference-paper

Abstract: We report on a microsystem integrating capillary microfluidics and impedance sensors for controlled on-chip nanoreceptor assembly and label-free antibody sensing.Leveraging engineered surface tension in open-channel capillary microfluidic pumps and stop valves, genetically engineered Tobacco mosaic virus-like particle (VLP) nanoreceptors are autonomously delivered and assembled onto the impedance microsensor.The evaporation-assisted VLP assembly shortens the time required for sensor functionalization to 6 minutes, a significant reduction in time compared with the VLP self-assembly process.Such VLP-functionalized impedance sensors can perform label-free antibody detection down to 10 ng/mL within 5 minutes.This platform has demonstrated great potential in on-demand portable biosensing.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2016.93

Authors: F. Zang, S. Chu, K. Gerasopoulos, J.N. Culver, R. Ghodssi

Institutions: Institute for Bioscience and Biotechnology Research, University of Maryland, College Park

Language: English

Topic: Microfluidic and Capillary Electrophoresis Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2925709674

FWCI:

Cites: 8

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Related to: 10