Formation of enantioenriched alkanol with stochastic distribution of enantiomers in the absolute asymmetric synthesis under heterogeneous solid–vapor phase conditions
Year: 2019
Type: article
Abstract: Among several theories proposed for the origin of homochirality, absolute asymmetric synthesis is unique because it produces chiral compounds without the intervention of any chiral factor. Here we report on the kinetically controlled heterogeneous solid-vapor phase absolute asymmetric synthesis in conjunction with asymmetric autocatalysis with amplification of chirality. Each reaction, carried out in a test tube, between achiral powder crystals of pyrimidine-5-carbaldehyde and the vapor of diisopropylzinc, is controlled kinetically to afford either (S)- or (R)-pyrimidyl alkanol.
Source: Chemical Communications
DOI: 10.1039/c9cc01875a
Institution: Tokyo University of Science
Language: English
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Awards: G2773049560, Asymmetric induction by the isotope chirality and cryptochirality for the highly sensitive chiral discrimination, G3759125080, 不斉自己触媒反応を用いる超高感度不斉認識の研究, G4181498285, Spontaneous formation, amplification and multiplication of enantioenriched aminonitriles by using circularly polarized light and quartz as origins of chirality, G5453499722, Study on the Origin of Chirality of Chiral Compounds by Using Asymmetric Autocatalysis, Asymmetric Autocatalysis Induced by Crystal or Surface Chirality of Achiral Compounds, Carbon Isotopically Chiral Compound Induced Enantioselective Amino acid Synthesis
OpenAlex ID: W2926343243