Work

The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled

Year: 2019

Type: article

Abstract: The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study. The aim was to determine the accuracy of product labels, and to identify known hepatotoxins. Using high-performance liquid chromatography coupled with mass spectrometry to assay 272 product, 51% were found to be mislabeled; that is, to have chemical contents that did not match the label. Appearance enhancement, sexual performance, and weight loss products were most commonly mislabeled. Whether the mislabeling contributed to liver injury is under study; however, the high mislabeling rate underscores the need for more stringent regulation of supplements.

Source: Hepatology Communications

DOI: 10.1002/hep4.1346

Authors: Victor Navarro, Bharathi Avula, Ikhlas Khan, Manisha Verma, Leonard Seeff, Jose Serrano, Andrew Stolz, Robert Fontana, Jawad Ahmad

Institutions: Einstein Healthcare Network, University of Mississippi, National Institute of Diabetes and Digestive and Kidney Diseases, University of Southern California, University of Michigan, Michigan Medicine, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Pharmaceutical Quality and Counterfeiting

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Bristol-Myers Squibb, Gilead Sciences, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1436523081, IU Clinical Center: Drug Induced Liver Injury Network, G151959291, Coordinating Center for the Drug Induced Liver Injury Network (DILIN), G38283659, Mount Sinai Regional Drug Induced Liver Injury Network Site, G7509555212, Michigan Hepatotoxicity Clinical Research Network Renewal, G884701208, Herbal and Dietary Supplement Induced Liver Injury in the U.S., University of North Carolina Clinical Center for DILIN, USC-UCLA Drug-Induced Liver Injury (DILI) Clinical Center

OpenAlex ID: W2926569512

FWCI: 5.091

Cites: 2

Cited by: 51

Related to: 10