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Exogenous Vasohibin-2 Exacerbates Angiotensin II-Induced Ascending Aortic Dilation in Mice

Year: 2019

Type: article

Abstract: Background: Chronic angiotensin II (AngII) infusion promotes ascending aortic dilation in C57BL/6J mice. Meanwhile, vasohibin-2 (VASH2) is an angiogenesis promoter in neovascularization under various pathologic conditions. The aim of this study was to investigate whether exogenous VASH2 influences chronic AngII-induced ascending aortic dilation.

Source: Circulation Reports

DOI: 10.1253/circrep.cr-19-0008

Authors: Michihiro Okuyama, Haruhito A. Uchida, Yoshiko Hada, Yuki Kakio, Nozomu Otaka, Ryoko Umebayashi, Katsuyuki Tanabe, Yasuhiro Fujii, Shingo Kasahara, Venkateswaran Subramanian, Alan Daugherty, Yasufumi Sato, Jun Wada

Institutions: University of Kentucky, Okayama University, Tohoku University, Institute of Development, Aging and Cancer, Tohoku University

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministry of Education, Culture, Sports, Science and Technology, National Institutes of Health, Japan Society for the Promotion of Science

Award: Molecular mechanism of Vasohibin-2 on development of abdominal aortic aneurysm

OpenAlex ID: W2926850566

FWCI: 1.446

Cites: 48

Cited by: 10

Related to: 10