Work

Discovery of False Elite Controllers: HIV Antibody-Positive RNA-Negative Blood Donors Found To Be on Antiretroviral Therapy

Year: 2019

Type: article

Study design: Observational Study

Abstract: BACKGROUND: An increase in potential HIV elite controllers (EC) and anecdotal reports of antiretroviral therapy (ART) use among South African blood donors led us to verify EC status. METHODS: Stored plasma samples from potential EC were tested for ART drugs. Demographic and temporal associations were examined using multivariable logistic regression. RESULTS: Of 226 potential EC, 150 (66.4%) had detectable ART with increasing prevalence by year (OR = 7.57 for 2016 vs 2010, 95% confidence interval, 1.96-32.17). DISCUSSION: False presumptive EC status due to undisclosed ART represents a growing proportion of potential EC donors in South Africa coincident with the country's ART rollout.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiz145

Authors: Wendy Sykes, Karin Van den Berg, Genevieve Jacobs, Adam Jauregui, Nareg Roubinian, Lubbe Wiesner, Gary Maartens, Ronel Swanevelder, Brian Custer, Michael Busch, Ute Jentsch, Edward L Murphy, Marion Vermeulen, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

Institutions: South African National Blood Service, Vitalant Research Institute, University of California, San Francisco, University of Cape Town

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center

Awards: G1328569733, G2048393990, G2818629771, International Traineeships in AIDS Prevention Studies (ITAPS), G567847597, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, Blood Research and EnhAnced Training against HIV in South Africa (BREATH-SA), AIDS Clinical Trial Group Laboratory Center, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG)

OpenAlex ID: W2927049794

FWCI: 2.947

Cites: 14

Cited by: 33

Related to: 10