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DOUBLE-SIDED MICROPILLAR ARRAYS FOR CELL CONTRACTION FORCE MAPPING USING OPTICAL MOIRé METHOD

Year: 2014

Type: conference-paper

Abstract: The mapping of cellular traction forces is fundamental to deeply understanding a wide range of cellular functions and behaviors.The moiré phenomenon has been leveraged as a visualization tool for cellular force mapping, yielding both a magnification effect as well as the capacity for whole-field force measurements.This paper reports the development of a doublesided micropillar array (DMPA) made of PDMS for use in moirébased cellular force analyses.Herein, the fabricated DMPAs were validated by mapping neonatal rat ventricular myocyte (NRVM) contraction forces.The advantages of the DMPA-based approach yield an improved moiré contrast and enable efficient moiré pattern generation.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2014.43

Authors: F. Zhang, S.W. Anderson, X. Zheng3, Y. Qiu4, R. Liao4, X. Zhang

Institutions: Boston University, Boston Medical Center, Lawrence Livermore National Laboratory, Brigham and Women's Hospital

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2927093705

FWCI:

Cites: 5

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Related to: 10