Progress in the expression of P-glycoprotein in brain metastases of lung cancer and related TCM research
Year: 2018
Type: article
Abstract: Brain metastases are common intracranial tumors, and their occurrence not only represents a high degree of malignancy, but also often a major factor in treatment failure and poor prognosis. Primary site of brain metastases often occur in lung. P-glycoprotein is a member of the (ATP binding cassette) transporter superfamily, which is closely related to the development of lung metastases. It is the main reason for influencing the drug through the blood-brain barrier into the brain tissue, and also an important factor affecting the treatment of brain metastases. According to the theory of traditional Chinese medicine, the pathogenesis of brain metastases is due to phlegm, poison, stasis, virtual and so on. The principle of treatment is to resuscitate, promote blood circulation, remove phlegm turbidity and so on. In recent years, the impact of Chinese herbal medicine on P-glycoprotein is increasing. This paper analyzes the mechanism and components of the relevant Chinese medicine on P-glycoprotein. It provides a reference for clinical rational drug use.
Source: Medical Theory and Hypothesis
Authors: Shuai Zhu, LingYu Qi, Xue Wang, HuaYao Li, Jia Li, Jing Yang
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4321511314