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Acetyl-cholinesterase Inhibition by Extracts and Isolated Flavones from Linaria reflexa Desf. (Scrophulariaceae)

Year: 2007

Type: article

Abstract: Extracts, linariin, isolinariin A and B obtained from Linaria reflexa Desf. (Scrophulariaceae) were tested for acetylcholinesterase inhibition activity using Ellman's method. A dose-response relationship was observed for all extracts and isolated compounds. Flavones exhibited IC 50 values ranging from 0.27 μM to 0.30 μM. The structure-activity relationship was briefly discussed.

Source: Natural Product Communications

DOI: 10.1177/1934578x0700200711

Authors: Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Marco Bonesi, Giancarlo Antonio Statti, Brigitte Deguin, François Tillequin, Francesco Menichini, Peter J Houghton

Institutions: University of Calabria, Centre National de la Recherche Scientifique, Université Paris Descartes, King's College London

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2929045736

FWCI: 0.421

Cites: 30

Cited by: 8

Related to: 10