Work

Localized Bionanoreceptor 3d-assembly Via Electrowetting: an Integrated Micro/nano/bio Fabrication Technology

Year: 2016

Type: conference-paper

Abstract: This work presents localized functionalization of bionanoreceptors, genetically modified Tobacco mosaic viruses, on high-aspect-ratio micropillar arrays using electrowetting principles.This approach allows wetting of the structurally hydrophobic component with TMV solution resulting in a near-complete coverage (~95%) of TMVs over the dense microstructures with clear functionalization boundaries.The functionalization morphology and biochemical activity of the electrowetted TMVs are confirmed using SEM and fluorescent labeling, respectively.A 5-fold increase in fluorescence intensity is achieved with µPAs over planar substrate.The TMV-based hierarchical functional structure enabled by electrowetting can serve as a high-surface-area component for next generation micro-devices.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2016.44

Authors: S. Chu, F. Zang, A.D. Brown, J.N. Culver, R. Ghodssi

Institutions: Institute for Bioscience and Biotechnology Research, University of Maryland, College Park

Language: English

Topic: Electrowetting and Microfluidic Technologies

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2929503772

FWCI: 0.469

Cites: 6

Cited by: 1

Related to: 10