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Elevated LRRK2 and α-synuclein levels in CSF of infectious meningitis patients

Year: 2019
Type: preprint
Study design: Observational Study
Abstract: Neurodegenerative diseases such as Parkinson’s (PD) have a complex aetiology consisting of an interplay of genetic and environmental factors. Inflammation and infection are proposed external factors that trigger disease progression. Tuberculous and cryptococcal meningitis frequently lead to long-term neurological sequelae but their association with the development of PD are unexplored. In this study, we protein profiled the CSF from 76 patients with or without infectious meningitis and found that proteins commonly associated with PD (LRRK2, tau and alpha-synuclein) were significantly elevated, establishing a link between neuroinflammation and infection. Importantly, these findings suggest that LRRK2, tau and alpha-synuclein could represent biomarkers of neuroinflammation.
DOI: 10.1101/599381
Authors: Susanne Herbst, Suzaan Marais, Maximiliano G. Gutierrez, Simon J Waddell, Robert J. Wilkinson, Rachel PJ Lai
Institutions: The Francis Crick Institute, University of Cape Town, Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of KwaZulu-Natal, University of Sussex, Imperial College London
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: green
Awards: STEROID PROTECTION FROM TUBERCULOSIS-ASSOCIATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME, G1288721568, G130052744, Host and bacillary factors in the pathogenesis of tuberculous meningitis., G2301282499, G3727094181, G4115567365, G4791776336, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Host directed therapies against tuberculosis., G6595762086, G7210654649, G724356770, G7364435899, G7497857799, G7574714948, G790109484, G8116470440
OpenAlex ID: W2931493354
Cites: 18
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Related to: 10