Work

Regulation of Transmembrane Signaling by Phase Separation

Year: 2019

Type: review

Abstract: Cell surface transmembrane receptors often form nanometer- to micrometer-scale clusters to initiate signal transduction in response to environmental cues. Extracellular ligand oligomerization, domain-domain interactions, and binding to multivalent proteins all contribute to cluster formation. Here we review the current understanding of mechanisms driving cluster formation in a series of representative receptor systems: glycosylated receptors, immune receptors, cell adhesion receptors, Wnt receptors, and receptor tyrosine kinases. We suggest that these clusters share properties of systems that undergo liquid-liquid phase separation and could be investigated in this light.

Source: Annual Review of Biophysics

DOI: 10.1146/annurev-biophys-052118-115534

Authors: Lindsay B. Case, Jonathon A. Ditlev, Michael K. Rosen

Institutions: Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Award: G245217697