Work

Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease

Year: 2019

Type: article

Abstract: INTRODUCTION: Numerous omics studies have been conducted to understand the molecular networks involved in Alzheimer's disease (AD), but the pathophysiology is still not completely understood; new approaches that enable neuroscientists to better interpret the results of omics analysis are required. METHODS: We have developed advanced methods to analyze and visualize publicly-available genomics and genetics data. The tools include a composite clinical-neuropathological score for defining AD, gene expression maps in the brain, and networks integrating omics data to understand the impact of polymorphisms on AD pathways. RESULTS: We have analyzed over 50 public human gene expression data sets, spanning 19 different brain regions and encompassing three separate cohorts. We integrated genome-wide association studies with expression data to identify important genes in the pathophysiology of AD, which provides further insight into the calcium signaling and calcineurin pathways. DISCUSSION: Biologists can use these freely-available tools to obtain a comprehensive, information-rich view of the pathways in AD.

Source: Alzheimer s & Dementia

DOI: 10.1016/j.jalz.2019.01.011

Authors: Nathan A. Bihlmeyer, Emily Merrill, Yann Lambert, Gyan P. Srivastava, Timothy W. Clark, Bradley T. Hyman, Sudeshna Das

Institutions: Harvard University, Massachusetts General Hospital, Centre d'Investigation Clinique Antilles Guyane, AbbVie (United States), University of Virginia

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Arizona Department of Health Services, Arizona Biomedical Research Commission, National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: Epidemiologic Study of Neural Reserve and Neurobiology of Aging, G1258278173, G2345704987, Epidemiologic Study of TDP-43 Pathology in Aging and Dementia, Gene discovery in PSP by transcriptome, neuropathology and sequence analysis, Targeted Proteomics of Resilient Cognition in Aging, Plasma AB as a Surrogate Genetic Marker for LOAD, Exploring the Role of the Brain Transcriptome in Cognitive Decline, G3186481112, National Alzheimer's Coordinating Center, THE HUMAN BRAINOME:genome, transcriptome and proteome interaction in human cortex, Pathway discovery, validation and compound identification for Alzheimer's disease, Alzheimers Disease Patient Registry, Einstein Aging Study, G4440353152, Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences, APOEomic: Searching for APOE interacting risk factors using omics data, Risk Factors, Pathology, and Clinical Expressions of AD, The Clinical Profile of Parkinson's Disease (PD) Pathology, Rush Alzheimer's Disease Core Center, G6030318873, Florida Alzheimer's Disease Research, Genome wide association study of gene expression levels in Alzheimer's disease, Arizona Alzheimer's Disease Core Center, Tau and Neurodegeneration II: A therapeutic target, A Systems Approach to Targeting Innate Immunity in AD, Massachusetts Alzheimer's Disease Research Center, National Brain and Tissue Resource for Parkinson's Disease and Related Disorders, Development of Lewy Bodies Biofluid Signatures by Targeted Proteomics, Characterizing the Behavior Profile of Healthy Cognitive Aging, THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE, Massachusetts Alzheimer's Disease Research Center (MADRC), G947960016, Mayo Alzheimer's Disease Research Center, G970642137

OpenAlex ID: W2932270119

FWCI: 2.345

Cites: 59

Cited by: 19

Related to: 10