Year: 2014
Type: conference-paper
Abstract: A novel Virus-like-particle (VLP) bioreceptor layer has been integrated with an optical microdisk resonator platform for biosensing applications.This bioreceptor layer can be genetically programmed for selective binding.An optical microdisk resonator has been functionalized for antibody binding with this receptor, demonstrating resonant frequency shifts of (Δfo) of 0.79 nm and 5.95nm after primary antibody binding and full enzyme linked immunosorbent assay (ELISA), respectively.These shifts are more than 300% higher compared to the non-specific binding of a control (non-conjugated) bioreceptor layer.The sensitivity of the optical resonator to detect primary antibody binding without the additional ELISA steps demonstrates the feasibility of this platform for rapid and simplified immunoassays on a chip.
Authors: X.Z. Fan, L. Naves, N.P. Siwak, A. Brown, J. Culver, R. Ghodssi
Language: English
Topic: Photonic and Optical Devices
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2932661948