Year: 2019
Type: article
Study design: Observational Study
Abstract: Except for drinking water, most beverages taste bitter or sweet. Taste perception and preferences are heritable and determinants of beverage choice and consumption. Consumption of several bitter- and sweet-tasting beverages has been implicated in development of major chronic diseases. We performed a genome-wide association study (GWAS) of self-reported bitter and sweet beverage consumption among ~370 000 participants of European ancestry, using a two-staged analysis design. Bitter beverages included coffee, tea, grapefruit juice, red wine, liquor and beer. Sweet beverages included artificially and sugar sweetened beverages (SSBs) and non-grapefruit juices. Five loci associated with total bitter beverage consumption were replicated (in/near GCKR, ABCG2, AHR, POR and CYP1A1/2). No locus was replicated for total sweet beverage consumption. Sub-phenotype analyses targeting the alcohol, caffeine and sweetener components of beverages yielded additional loci: (i) four loci for bitter alcoholic beverages (GCKR, KLB, ADH1B and AGBL2); (ii) five loci for bitter non-alcoholic beverages (ANXA9, AHR, POR, CYP1A1/2 and CSDC2); (iii) 10 loci for coffee; six novel loci (SEC16B, TMEM18, OR8U8, AKAP6, MC4R and SPECC1L-ADORA2A); (iv) FTO for SSBs. Of these 17 replicated loci, 12 have been associated with total alcohol consumption, coffee consumption, plasma caffeine metabolites or BMI in previous GWAS; none was involved in known sweet and bitter taste transduction pathways. Our study suggests that genetic variants related to alcohol consumption, coffee consumption and obesity were primary genetic determinants of bitter and sweet beverage consumption. Whether genetic variants related to taste perception are associated with beverage consumption remains to be determined.
Source: Human Molecular Genetics
DOI: 10.1093/hmg/ddz061
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: American Heart Association, Amgen, Northwestern University, National Institutes of Health, Quest High Performance Computing, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Eye Institute, National Cancer Institute, National Institute on Deafness and Other Communication Disorders
Awards: GWAS on childhood body fatness as an intermediate phenotype of breast cancer, Women's Health Study: Continued Follow-Up, G1214533002, Atypical Bacterial Infection as an Asthma Risk Factor, Biochemical Markers in the nurses' Health Study Cohort, Gene-Environment Interactions in Glaucoma, Dietary Etiologies of Heart Disease, G361298724, Dietary and Hormonal Determinants of Cancer in Women, Genes and Environment Initiative in Glaucoma, The Pathobiology of Nephrolithiasis, G558986044, The Women's Health Study: Infrastructure Support for Continued Cohort Follow-up, G6008908520, G6245922197, G631129105, Prospective Studies of Diet and Cancer in Men and Women, Genetic Determinants of Taste Preferences and Risk of Metabolic Disease, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Risk Factors for Breast Cancer in Younger Nurses, Women's Health Study: Continued Follow-up, Cancer Epidemiology Cohort in Male Health Professionals, G7962241407, Women's Health Study: Infrastructure support for cohort follow-up, G8193320900, G8373674595, P30 Core Grant for Vision Research, NEIGHBORHOOD Consortium for POAG Genetics, RISK FACTORS FOR CVD IN WOMEN, Risk Factors for Ischemic Stroke in Women, Cancer Epidemiology Cohort in Male Health Professionals
OpenAlex ID: W2933157483