Work

Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity

Year: 2019

Type: article

Source: Cell chemical biology

DOI: 10.1016/j.chembiol.2019.02.015

Authors: Fleur M. Ferguson, Zainab M. Doctor, Scott B. Ficarro, Christopher M. Browne, Jarrod A. Marto, Jared L. Johnson, Tomer M. Yaron, Lewis C. Cantley, Nam Doo Kim, Taebo Sim, Matthew J. Berberich, Marian Kalocsay, Peter K. Sorger, Nathanael S. Gray

Institutions: Harvard University, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Dana-Farber Brigham Cancer Center, Dana-Farber/Harvard Cancer Center, Weill Cornell Medicine, Daegu-Gyeongbuk Medical Innovation Foundation, Korea University, Korea Institute of Science and Technology

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Astellas Pharma US, Merck, Novartis, Sanofi, Dana-Farber Cancer Institute, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: (PQ5) Contribution of mitochondrial pathways to metabolic heterogeneity in molecular subtypes of Diffuse Large B Cell Lymphoma, The HMS Laboratory of Systems Pharmacology, G276924847, Phosphoproteomic signatures for early detection and stratification of AML, Illuminating Function of the Understudied Druggable Kinome, G6558109815, G6680829801, G775640930, Pharmaco Response Signatures and Disease Mechanism, G8750350201, Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism

OpenAlex ID: W2934863159

FWCI: 1.336

Cites: 53

Cited by: 31

Related to: 10