Work

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

Year: 2019

Type: review

Abstract: Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of atherosclerosis and a significant risk factor for the development of cardiovascular events. In the crosstalk between inflammation and cardiovascular diseases, the transcription factor NFκB seems to be a key player since it is involved in the development and progression of both inflammation and cardiac and vascular damage. In this review, we deal with the recent findings of the role of inflammation in cardiac diseases, focusing, in particular, on NFκB as a functional link. We describe strategies for the therapeutic targeting of NFκB as a potential strategy for the failing heart.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms20071599

Authors: Antonella Fiordelisi, Guido Iaccarino, Carmine Morisco, Enrico Coscioni, Daniela Sorriento

Institutions: University of Naples Federico II, AOU San Giovanni di Dio e Ruggi d'Aragona

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,824