Get started
Work

Ultrasound guided generation of PDOX models of adenoid cystic carcinoma

Year: 2019
Type: article
Abstract: Adenoid cystic carcinomas (ACC) represent a rare type of head and neck cancer that remain clinically persistent for decades despite aggressive multimodal intervention [1]. Successful development of clinically-relevant animal models of ACC is critical to improve our understanding of the mechanisms of salivary tumourigenesis and to develop novel therapies against this disease. To this end, Cornett et al. [2] have recently shown that patient-derived orthotopic xenograft (PDOX) models of ACC maintain high fidelity to human tumours and exhibit several hallmarks of human disease including innervation since ACCs are notorious for perineural invasion.
Source: EBioMedicine
DOI: 10.1016/j.ebiom.2019.03.084
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,500
Funders: Roswell Park Cancer Institute, Roswell Park Alliance Foundation, Roswell Park Cancer Institute, Center for Outcomes Research and Evaluation, Yale School of Medicine, National Institutes of Health, National Cancer Institute, National Institute of Dental and Craniofacial Research
Awards: Photoacoustic Micro-Imaging system for Shared Tumor Imaging Resource at Roswell P, G215985982, G3474214686, G3574139009, G4835291745, G5503219858, G6736105207, G9000003107, Roswell Park Cancer Center Support Grant
OpenAlex ID: W2935676546
FWCI: 0.216
Cites: 5
Cited by: 2
Related to: 10