Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Women with gestational diabetes mellitus (GDM) may be at an increased risk of liver complications because chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking. METHODS: The Diabetes & Women's Health Study (2012-2014) examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort. Nine to 16 years postpartum, a clinical examination was performed, with measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, from which fatty liver scoring indices were calculated to assess liver fat score, fatty liver index, hepatic steatosis index, and liver fat percentage. Relative risks (RR) with 95% confidence intervals (CI) for elevated liver scoring indices by GDM status were assessed adjusting for major risk factors, including prepregnancy body mass index. RESULTS: Women with prior GDM had higher adjusted ALT and AST levels than women without GDM (by 6.7% [95% CI 1.7-12.0] and 4.8% [95% CI 0.6-9.1], respectively). Women with GDM also had adjusted increased risks for elevated liver fat score (RR 2.34; 95% CI 1.68-3.27), fatty liver index (RR 1.59; 95% CI 1.27-1.99), and hepatic steatosis index (RR 1.44; 95% CI 1.21-1.71). CONCLUSIONS: Women with GDM during pregnancy were at an increased risk for fatty liver 9 to 16 years postpartum. Gestational diabetes mellitus may serve as another risk indicator for the early identification and prevention of liver fat accumulation.
Source: Journal of Diabetes
Authors: Sarah R. Donnelly, Stefanie N. Hinkle, Shristi Rawal, Louise G. Grunnet, Jorge E. Chavarro, Allan Vaag, Jing Wu, Peter Damm, James L. Mills, Mengying Li, Anne A. Bjerregaard, Anne Cathrine B. Thuesen, Robert E. Gore‐Langton, Ellen C. Francis, Sylvia H. Ley, Frank B. Hu, Michael Y. Tsai, Sjurdur F. Olsen, Cuilin Zhang
Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Virginia Tech, Rutgers, The State University of New Jersey, Rutgers Health, Rigshospitalet, Danish Diabetes Academy, Brigham and Women's Hospital, Harvard University, AstraZeneca (Sweden), Glotech (United States), University of Copenhagen, Statens Serum Institut, Emmes (United States), Clemson University, University of Minnesota
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: March of Dimes Foundation, Hjerteforeningen, Innovationsfonden, Danish Diabetes Academy, European Commission, Novo Nordisk, Novo Nordisk Fonden, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1432259938, G1655263665, G1697744707, G2193368973, G2575332759, G2583549010, G3078662949, G3460739205, Diabetes & Women's Health Study: long term health implications of GDM, G4135085062, G4340902257, G4876999151, G4992784775, G5151218667, G550592765, G5993640964, G6491228255, G7910773038, G8223993039, Long-term effects of early nutrition on later health, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases
OpenAlex ID: W2935904657