Work

Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management

Year: 2019

Type: review

Abstract: Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coagulation defects, and metabolic disorders all have been implicated in the pathogenesis of NE. At present, therapeutic hypothermia is the only treatment available, regardless of etiology. Recognizing the etiology of NE involved can also guide investigations such as metabolic and sepsis workups to ensure optimal management. Understanding the etiology of NE may allow the development of targeted adjunctive therapies related to the underlying mechanism and develop preventative strategies.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2019.00142

Authors: Saima Aslam, Tammy Strickland, Eleanor J. Molloy

Institutions: University College Dublin, National Maternity Hospital, Trinity College Dublin, Coombe Women & Infants University Hospital

Language: English

Topic: Neonatal and fetal brain pathology

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490