Work

Metabolic Stress

Year: 2019

Type: review

Abstract: Mitochondria regulate major aspects of cell function by producing ATP, contributing to Ca 2+ signaling, influencing redox potential, and controlling levels of reactive oxygen species. In this review, we will discuss recent findings that illustrate how mitochondrial respiration, Ca 2+ handling, and production of reactive oxygen species affect vascular smooth muscle cell function during neointima formation. We will review mitochondrial fission/fusion as fundamental mechanisms for smooth muscle proliferation, migration, and metabolism and examine the role of mitochondrial mobility in cell migration. In addition, we will summarize novel aspects by which mitochondria regulate apoptosis.

Source: Arteriosclerosis Thrombosis and Vascular Biology

DOI: 10.1161/atvbaha.118.312196

Authors: Isabella M. Grumbach, Emily K. Nguyen

Institutions: University of Iowa, Iowa City VA Health Care System, Iowa City VA Medical Center, University of Iowa Holden Comprehensive Cancer Center

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green