0121 Quantitative Anisotropy Within The Default-mode Network Predicts Mood Degradation Following Sleep-deprivation
Year: 2019
Type: conference-abstract
Abstract: Sleep deprivation (SD) adversely affects cognition and mood, but some individuals show a trait-like resistance to these effects. The default mode network (DMN), in particular, appears to play a key role in emotional regulation. We hypothesized that individuals with greater white-matter quantitative anisotropy (QA), i.e., greater compactness of white-matter paths, and thicker cortex for regions within the DMN, would demonstrate greater “resistance” to SD with regard to mood degradation across the overnight period without sleep. Diffusion-weighted and T1-weighted data were collected from 45 healthy individuals prior to a SD protocol during which the Visual Analog Mood Scale (VAMS) was used every hour from 19:15 (time point1; TP1) to 11:15 (TP17) the following morning to measure two positive and three negative mood states. Four spherical regions of radius 12 mm within the DMN - the posterior cingulate cortex (PCC), middle prefrontal cortex (MPFC) and bilateral lateral parietal cortices (L.LPC/R.LPC) were used as regions of interest (ROIs). The index of mood resistance (IMR) was defined as the averaged differences between positive and negative mood states over 12 TPs (TP5 to TP16) relative to averaged differences at baseline (TP1 to TP4). Data from the last TP i.e., at TP17 was not included in the analysis. Age, sex, body-mass index and education were used as covariates. We found that there were significant positive associations between residualized IMR and QA within the MPFC (r = 0.33, p = 0.04), L.LPC (r = 0.46, p < 0.001) and R. LPC (r = 0.49, p < 0.001). We did not find significant association between IMR and thickness for any of the ROIs. Greater compactness of white-matter bundles, but not the morphometry, within the DMN plays a significant role in the ability to resist mood degradation over the course of a night of SD. Future work focusing on effective brain connectivity will be necessary to confirm the role of DMN and individual differences in positive and negative mood states separately. D12AP00241 (WDK)
Source: SLEEP
Institution: University of Arizona
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: bronze
OpenAlex ID: W2936925872