PO-060 Outcomes from concomitant cetuximab with radiotherapy in HNSCC: A retrospective cohort study
Year: 2019
Type: conference-abstract
Abstract: hemoglobin and serum albumin, before definitive radiation for head and neck squamous cell carcinoma (HNSCC) predict survival and locoregional control. Material and MethodsRetrospective study included patients with pathologically proven HNSCC undergoing definitive RT at a single tertiary level referral university cancer center, Alexandria Clinical Oncology Department (ACOD), during the period from January 1, 2005 to December 31, 2015.The effect of pre-RT BMI, serum hemoglobin and serum albumin on survival and disease control were evaluated.Results 215 patients met our inclusion criteria.Of these, 31 (14.4%) were women and 184 (85.6%) were men.Their mean age was 57.21 (+/-9.7).Laryngeal SCC constituted most of cases with 84 (39.06%) patients followed by oropharyngeal SCC with 69 (32.1%) patients.In multivariate analysis, BMI (</=25 vs >25) and hemoglobin (<=12g/dl vs >12g/dl for females and </=14g/dl vs >14g/dl for males) pre-RT correlated significantly with both survival ((HR, .409;95%CI, 0.254-0.659;P = <.0001) for BMI and (HR, .367;95%CI,0.211-0.639;P = <.0001) for hemoglobin) and locoregional control ((HR, .431;95%CI, 0.246-0.755;P = .003)for BMI and (HR, 2.554; 95%CI,1.328-4.911;P = .005)for hemoglobin).In contrast, Serum albumin showed insignificant correlation, both when taken as a continuous variable and when taken as a categorical variable (<3.5mg/dl vs =/>3.5mg/dl), with both survival (HR,1.035;95%CI,.429-2.498;P = .939)and locoregional control(HR,1.688;95%CI,.655-4.351;P=.279).Conclusion BMI and serum hemoglobin pre-treatment can predict oncologic outcomes for patients with HNSCC, whereas pretreatment serum albumin does not predict locoregional control nor survival.Our study can be the basis to use easy-to-obtain parameters like BMI and serum hemoglobin to stratify HNSCC patients who are in need for more indepth nutritional assessment and interventions pre-RT with hope of reflection on treatment outcome.
Source: Radiotherapy and Oncology
Authors: C. Paterson, A. Morton, C. Lamb, C. Wilson, D. Grose, M. Rizwanullah, S. Schipani, F. Easton, F. Campbell, A. James, M. Philip, M. Thomson
Institution: Beatson West of Scotland Cancer Centre
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,000
OpenAlex ID: W2937004716