Organ‐on‐a‐Chip: Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes (Adv. Sci. 8/2019)
Year: 2019
Type: article
Abstract: In article 1801531, Rong Fan and co-workers examine the dynamics of brain tumor cells in a microvasculature-on-a-chip system. Tumor cells residing in the perivascular zone show various degrees of co-localization with microvessels across ten glioblastoma patients. Single-cell transcriptome sequencing (21 750 single cells) reveals that brain tumor cells with high expression of PDGFRA preferentially localize in the perivascular niche.
Source: Advanced Science
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $5,000
OpenAlex ID: W2937060513