Year: 2019
Type: review
Abstract: One of the mechanisms responsible for blood pressure (BP) regulation is thought to be oxidative stress. In this review, we highlight preclinical studies that strongly support a role for oxidative stress in development and maintenance of hypertension in male animals, based on depressor responses to antioxidants, particularly tempol and apocynin. In females, oxidative stress seems to be important in the initial development of hypertension. However, whether maintenance of hypertension in females is mediated by oxidative stress is not clear. In clinical studies, pharmacological intervention to reduce BP with antioxidants has conflicting results, mostly negative. This review will discuss the uncertainties regarding blood pressure control and oxidative stress and potential reasons for these outcomes.
Source: Physiology
Institution: University of Mississippi Medical Center
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1575027660, G2063761228, G253628612, G3317640553, G4737602250, Humoral factors in gender differences in blood pressure control, G581947752, Cardiovascular Dynamics & Their Control, Cardiorenal and Metabolic Diseases Research Center, G9000115909, Mississippi Center of Excellence in Perinatal Research, Phase 2, Mississippi Center for Clinical and Translational Research
OpenAlex ID: W2937183901