Work

A Novel, Widespread qacA Allele Results in Reduced Chlorhexidine Susceptibility in Staphylococcus epidermidis

Year: 2019

Type: article

Abstract: Chlorhexidine gluconate (CHG) is a topical antiseptic widely used in health care settings. In Staphylococcus spp., the pump QacA effluxes CHG, while the closely related QacB cannot due to a single amino acid substitution.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02607-18

Authors: Amin Addetia, Alexander L. Greninger, Amanda Adler, Shuhua Yuan, Negar Makhsous, Xuan Qin, Danielle M. Zerr

Institutions: Seattle Children's Research Institute, University of Washington, Shanghai Jiao Tong University, Shanghai Children's Medical Center

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: St. Baldrick's Foundation, National Cancer Institute

Awards: Impact of chlorhexidine bathing on reducing infections in children with cancer, Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant

OpenAlex ID: W2937244516

FWCI: 1.916

Cites: 73

Cited by: 23

Related to: 10