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Impact of MET variants on PD-L1 expression in pleomorphic lung carcinoma

Year: 2019
Type: article
Study design: Observational Study
Abstract: Background: Pleomorphic Lung Carcinoma (PC) is a rare subtype of NSCLCs poorly responsive to systemic therapy. It is a heterogenous tumour with both epithelial and sarcomatoid components. MET variants are targetable aberrations and have recently been reported to be more frequent in PCs. The relationship between MET and PD-L1 expression is not well understood. We determined PD-L1 expression in PCs and its relationship with MET variants.
DOI: 10.1093/annonc/mdz072
Authors: A. Januszewski, Y.Z. Zhang, W.-C. Chang, U. Laggner, A. Bowman, T. Adefila-Ideozu, I. Vivanco, M.F. Moffatt, W.O. Cookson, N.P. Gupta, A.G. Nicholson, A. Bowcock, S. Popat
Institutions: Royal Marsden NHS Foundation Trust, Royal Marsden Hospital, Royal Brompton Hospital, Institute of Cancer Research, Imperial College London, Hammersmith Hospital
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $2,250
OpenAlex ID: W2937463510
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