Exosomes derived from cardiac telocytes exert positive effects on endothelial cells.
Year: 2017
Type: article
Abstract: , as well as transfusing them into a rat model of myocardial infarction. We confirmed that cultured telocytes exhibit normal characteristics, including long, thin prolongations with a moniliform appearance, as well as positive expression of c-Kit, CD34, and vimentin. Furthermore, we observed mitochondria throughout the cell body and telopodes, and found that telocytes actively secrete exosomes. Interestingly, endothelial cells cultured with telocyte supernatants or exosomes exhibited increased proliferation, migration, and formation of capillary-like structures, and these effects were attenuated when exosomes were depleted from telocyte supernatants. Finally, treating myocardial infarction-induced rats with telocyte exosomes resulted in decreased cardiac fibrosis, improved cardiac function, and increased angiogenesis. Taken together, our results provide novel insight into cardiac telocytes, suggesting that they communicate with neighboring endothelial cells via exosome secretion and that these exosomes exert potentially beneficially effects.
Source: PubMed
Authors: Jie Yang, Yanyan Li, Fengtai Xue, Wei Liu, Song Zhang
Institutions: Shanghai Jiao Tong University, XinHua Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2937810964