Work

Bone‐specific kinetic model to quantify periosteal and endosteal blood flow using indocyanine green in fluorescence guided orthopedic surgery

Year: 2019

Type: article

Abstract: This letter describes a hybrid plug/compartment (HyPC) kinetic model to fit dynamic indocyanine green fluorescence data acquired in a porcine model of long bone traumatic fracture. Parametric images of periosteal blood flow, endosteal blood flow, total bone blood flow and fraction of endosteal-to-periosteal flow were obtained by applying the HyPC model on a pixel-by-pixel basis. Intraoperative discrimination between healthy and damaged bone could facilitate debridement reducing post-operative complications from non-union and infection. The ability to quantify periosteal and endosteal blood flow could inform nail vs. plate-and-screw decisions to avoid further compromising cortical blood supply.

Source: Journal of Biophotonics

DOI: 10.1002/jbio.201800427

Authors: Jonathan T. Elliott, Shudong Jiang, Brian W. Pogue, Ida L. Gitajn

Institutions: Dartmouth College, Dartmouth–Hitchcock Medical Center

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Dartmouth College, National Institutes of Health, National Cancer Institute, National Center for Advancing Translational Sciences