Work

Progress of research on the immune tolerance of chronic HBV infection

Year: 2018

Type: article

Abstract: Immune tolerance is a specific lack or negative response of T and B lymphocytes to antigen. According to different formation periods, immune tolerance can be divided into central and peripheral tolerances. The immune tolerance of the body to hepatitis B virus (HBV) after infection is the main cause of chronic HBV infection. In this paper, the functional defects of hepatitis B virus e antigen and dendritic cells, hyporesponsiveness of cytotoxic T lymphocyte, variation of helper T lymphocytes and cytokines, HBV genotype and genome, and the role of host gene polymorphism in the formation of immune tolerance in chronic HBV infection and its related research progress are introduced briefly.

Source: Infection International/Infection International (Electronic Edition)

DOI: 10.2478/ii-2018-0026

Authors: Xuemei Li, Xiaoxia Li

Institutions: Capital Medical University, Xuan Wu Hospital of the Capital Medical University

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2938833539

FWCI:

Cites: 30

Cited by:

Related to: 10