Work

Exercise-Induced Mitophagy in Skeletal Muscle and Heart

Year: 2019

Type: review

Abstract: Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitochondria biogenesis, the selective degradation of dysfunctional mitochondria (i.e., mitophagy) also is a key component of exercise-mediated adaptations in striated muscle, which eventually leads to better mitochondrial functions.

Source: Exercise and Sport Sciences Reviews

DOI: 10.1249/jes.0000000000000192

Authors: Yuntian Guan, Joshua C. Drake, Zhen Yan

Institution: University of Virginia

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases