Work

Role of exercise-induced hepatokines in metabolic disorders

Year: 2019

Type: review

Abstract: The health-promoting effects of physical activity to prevent and treat metabolic disorders are numerous. However, the underlying molecular mechanisms are not yet completely deciphered. In recent years, studies have referred to the liver as an endocrine organ, since it releases specific proteins called hepatokines. Some of these hepatokines are involved in whole body metabolic homeostasis and are theorized to participate in the development of metabolic disease. In this regard, the present review describes the role of Fibroblast Growth Factor 21, Fetuin-A, Angiopoietin-like protein 4, and Follistatin in metabolic disease and their production in response to acute exercise. Also, we discuss the potential role of hepatokines in mediating the beneficial effects of regular exercise and the future challenges to the discovery of new exercise-induced hepatokines.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00433.2018

Authors: Gaël Ennequin, Pascal Sirvent, Martin Whitham

Institutions: Université Bourgogne Franche-Comté, Université Clermont Auvergne, Centre de Recherche en Nutrition Humaine d'Auvergne, Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques, University of Birmingham

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2939910523

FWCI: 0.6

Cites: 180

Cited by: 54

Related to: 10