Work

Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region

Year: 2019

Type: article

Abstract: During pregnancy, Plasmodium falciparum -infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit inflammatory responses that are associated with poor pregnancy outcomes. Primigravidae lack immunity to IE that sequester in the placenta and thus are susceptible to placental malaria (PM).

Source: Infection and Immunity

DOI: 10.1128/iai.00865-18

Authors: Justin Doritchamou, Andrew Teo, Robert Morrison, Gunjan Arora, Jennifer Kwan, Javier Manzella-Lapeira, Sarimar Medina-Maldonado, Jean Langhorne, Lars Hviid, David L. Narum, Alassane Dicko, Michal Fried, Patrick E. Duffy

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, The Francis Crick Institute, University of Copenhagen, Université des Sciences, des Techniques et des Technologies de Bamako, Malaria Research and Training Center

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Sundhed og Sygdom, Det Frie Forskningsråd, Wellcome Trust, Francis Crick Institute, Cancer Research UK, Novo Nordisk UK Research Foundation, Novo Nordisk, National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: G1804222254, G255699443, G4753740696, G5830407787, G7847775018, G8103042128, G866581451

OpenAlex ID: W2940027195

FWCI: 3.684

Cites: 61

Cited by: 22

Related to: 10