Work

Loss of BAP1 as a candidate predictive biomarker for immunotherapy of mesothelioma

Year: 2019

Type: article

Abstract: As trials of immune checkpoint inhibitor (ICI) therapies demonstrate responses in only a minority of pleural mesotheliomas (PlMs) and largely exclude patients with the related peritoneal mesothelioma (PeM), clinicians need predictive biomarkers of response and inclusion of PeM patients in future trials. A new study finds that loss of the deubiquitinase BAP1 in PeM correlates with an inflammatory tumor microenvironment, suggesting that BAP1 status might identify PeM, and possibly PlM, patients who would benefit from ICI therapy.

Source: Genome Medicine

DOI: 10.1186/s13073-019-0631-0

Authors: Marc Ladanyi, Francisco Sanchez Vega, Marjorie Zauderer

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Occupational and environmental lung diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,680