Work

The importance of circulating and disseminated tumor cells in pancreatic cancer

Year: 2019

Type: article

Abstract: Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell-like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future.

Source: Surgery Open Science

DOI: 10.1016/j.sopen.2019.08.002

Authors: Alina Hasanain, Barbara Aldana Blanco, Jun Yu, Christopher L. Wolfgang

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Boston Medical Center

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,400