Year: 2019
Type: article
Abstract: Pulmonary hypertension (PH) is an incurable disease characterized by pulmonary vascular remodeling and ultimately death. Two rodent models of PH include treatment with monocrotaline or exposure to a vascular endothelial growth factor receptor inhibitor and hypoxia. Studies in these models indicated that damaged lung cells evolve extracellular vesicles which induce production of progenitors that travel back to the lung and induce PH. A study in patients with pulmonary myelofibrosis and PH indicated that 100 cGy lung irradiation could remit both diseases. Previous studies indicated that murine progenitors were radiosensitive at very low doses, suggesting that 100 cGy treatment of mice with induced PH might be an effective PH therapy. Our hypothesis is that the elimination of the PH-inducing marrow cells by low dose irradiation would remove the cellular influences creating PH. Here we show that low dose whole-body irradiation can both prevent and reverse established PH in both rodent models of PH.
Source: Journal of Cellular Physiology
DOI: 10.1002/jcp.28723
Institutions: Brown University, Rhode Island Hospital, University of Turin
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: Basic Aspects of Hematopoietic Stem Cells and Aging, CardioPulmonary Vascular Biology COBRE, Stem Cell Biology: New Directions in Clinical and Basic Research, The Role of NPR-C In Modulation Of Acute Lung Injury, G3806333924, The role of endothelial to hematopoietic transition in the pathogenesis of pulmonary hypertension, Endothelial Plasticity in Human Disease, G4511054676, Hematology Post Doctoral Training, Stem Cells and Aging, G9000225961, Transfusion Biology and Cellular Therapies
OpenAlex ID: W2940988480