Mp66-03 Among Men With Gleason Grade Group 3, Intermediate-risk Prostate Cancer, Stage Ct2 Is Associated With Metastatic Recurrence
Year: 2019
Type: article
Study design: Observational Study
Abstract: PSA (OR.1.2, P[ 0.02) and maximum cancer percentage /core (OR.1.3, P[ 0.0001) were independent predictors of adverse pathology outcomes (table 1).In NCCN LR men with adverse pathological outcomes at RP had higher disease burden in the form of higher median number of positive cores (P[ 0.01), higher percent of positive cores (P[0.009),higher maximum cancer percentage/core (P[ 0.001).In both unadjusted (P[ 0.01) and logistic regression (OR.3, P[ 0.04) models, apical cancer location at PBx was associated with adverse pathological outcomes at time of RP. (Table 2)CONCLUSIONS: The presence of apical lesion on prostate biopsy in men with NCCN VLR/LR PCa increases the likelihood of adverse pathological outcomes on RP for those who go on to surgical treatment.Apical lesions are often under-sampled at time of prostate biopsy and may harbor unfavorable pathology.Men with apical lesion who elected AS may require additional apical sampling or mpMRI at time of confirmatory biopsy.
Source: The Journal of Urology
Authors: John Cooper*, Mufaddal Mamawala, Jason Cohen, Jeffrey Tosoian, Misop Han, Debasish Sundi
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2941015137