Work

Pd18-03 Comparison of Surveillance Regimens for Low Risk Non-muscle Invasive Bladder Cancer: a Pilot Study

Year: 2019

Type: article

Abstract: between responders and non-responders.Responders exhibited higher IL-8 levels at study entry and higher VEGF-A levels after Sunitinib; however, the changes seen in IL-8 (p[0.84) and VEGF-A (p[0.85) were not statistically significant.Responders exhibited lower VEGF-D levels until after Sunitinib at which point they developed a higher mean level and a greater change from study entry than non-responders.This effect was found to be statistically significant (p[0.04).CONCLUSIONS: The primary endpoint of our study was reached with 26 patients demonstrating 3-month CR.In addition, the statistically significant increase in VEGF-D levels in responders supports the theory that VEGF plays an important role in the pathogenesis of NMIBC and thus warrants further investigation.

Source: The Journal of Urology

DOI: 10.1097/01.ju.0000555575.00837.6a

Authors: Shane L. Barney*, Cory M. Hugen, Yair Lotan, Edward M. Messing, Robert S. Svatek

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Pfizer, Michigan Diabetes Research Center, University of Michigan, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1847454291, G301048564