Work

Modulating inflammation for cancer therapy

Year: 2019

Type: review

Abstract: A link between chronic inflammation and development of tumors is well established. Moreover, it has become evident that tumorigenesis is not a cell autonomous disease, and an inflammatory microenvironment is a prerequisite of basically all tumors, including those that emerge in the absence of overt inflammation. This knowledge has led to the development of anti-inflammatory concepts to treat and prevent cancer. In contrast, immunotherapies, in particular checkpoint inhibitors, representing the most significant progress in the therapy of several malignancies depend on the presence of a pro-inflammatory "hot" environment. Here, we discuss pro- and anti-inflammatory concepts for the treatment of cancer.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20181739

Authors: Birgit Ritter, Florian R. Greten

Institutions: Georg Speyer Haus, Goethe University Frankfurt, German Cancer Research Center, Frankfurt Cancer Institute, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Gesundheit