Work

Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post‐natal offspring early life phenotype

Year: 2019

Type: article

Abstract: BACKGROUND: Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months. METHODS: Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation. RESULTS: Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups. CONCLUSIONS: Mismatch produces sexually dimorphic post-natal growth phenotypes.

Source: Journal of Medical Primatology

DOI: 10.1111/jmp.12415

Authors: Cun Li, Susan Jenkins, Hillary F. Huber, Peter W. Nathanielsz

Institutions: University of Wyoming, Texas Biomedical Research Institute

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development