Year: 2019
Type: article
Abstract: Fiber-based imaging of tissue autofluorescence using ultraviolet (UV) excitation is a highly flexible tool used to probe structure and composition. In this Letter, we report, to the best of our knowledge, the first results from a single-fiber imaging system employing a custom double-clad fiber to acquire multispectral fluorescence lifetime images at two distinct spatial resolutions. We characterize the lateral point spread function and fluorescent background of the system and show how enhanced resolution can identify features such as trabeculae in ex vivo murine bone samples.
Source: Optics Letters
DOI: 10.1364/ol.44.002302
Institution: University of California, Davis
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: green
Awards: G2593696852, Multi-modal technology for non-destructive characterization of bioengineered tissues, Bimodal platform for nondestructive analysis of engineered vascular biomaterials, Multimodal platform combining optical and ultrasonic technologies for in vivo nondestructive evaluation of engineered vascular tissue constructs
OpenAlex ID: W2942043787