Mp20-03 Development and Validation of Patient Specific Hydrogel Kidney Phantoms in Predicting Partial Nephrectomy Success for Complex Renal Masses
Year: 2019
Type: article
Abstract: near-infrared spectrum.A porcine surgical model was used for this experiment. During data collection, the tissue is exposed to white light, without contrast materials, and the light absorbed or reflected from the tissue is analyzed.Utilizing liquid crystal technology, MCI-E generates real-time wavelength-specific imagery targeting tissue structures, and resulting detections are overlaid onto conventional high definition video.To evaluate detection performance, the contrast between the target tissue and surrounding tissues is quantified with the signal-to-noise ratio (SNR) and area under the ROC curve(AUC).RESULTS: We demonstrate MCI-E enhanced visualization of several important tissues against the background.The ureter is visualized against background tissues with AUC of 0.90 and SNR of 2.3.Artery and vein are differentiated from their surrounding tissues with AUC of 0.97, 0.98 and SNR of 4.75 and 4.39 respectively.Lymph nodes are visualized with AUC of 0.97 and SNR of 4.8.The neurovascular bundle is visualized with AUC of 0.98 and SNR of 3.1.In addition, we showed that MCI-E is able to distinguish ischemic bowel from non-ischemic bowel with high accuracy (AUC of 0.97 and SNR of 4.3).MCI-E is capable of locating obscured objects inside lumens and in the presence of fat or blood.For this experiment, we used gallstones with different sizes and put them inside different locations of the biliary tree.The obscured stones could be detected with AUC of 0.99 and SNR of 3.8.CONCLUSIONS: Real-time, high contrast MCI-E detections in vivo demonstrate the potential of this new imaging modality for enabling a surgeon to discriminate critical structures intraoperatively and without contrast agents.
Source: The Journal of Urology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2942369162