Increased epigenetic age in normal breast tissue from luminal breast cancer patients
Year: 2018
Type: other
Abstract: Background Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood. Quantifying tissue-level DNA methylation can contribute to understanding these processes. We hypothesized that occurrence of breast cancer should be associated with an acceleration of epigenetic aging in normal breast tissue. Results Ninety-six normal breast tissue samples were obtained from 88 subjects (breast cancer = 35 subjects/40 samples, unaffected = 53 subjects/53 samples). Normal tissue samples from breast cancer patients were obtained from distant non-tumor sites of primary mastectomy specimens, while samples from unaffected women were obtained from the Komen Tissue Bank (n = 25) and from non-cancer-related breast surgery specimens (n = 28). Patients were further stratified into four cohorts: age
Source: Figshare
Authors: Hofstatter, Erin, Horvath, Steve, Disha Dalela, Piyush Gupta, Anees Chagpar, Wali, Vikram, Bossuyt, Veerle, Storniolo, Anna, Hatzis, Christos, Patwardhan, Gauri, Marie-Kristin Von Wahlde, Butler, Meghan, Epstein, Lianne, Stavris, Karen, Sturrock, Tracy, Au, Alexander, Kwei, Stephanie, Pusztai, Lajos
Institutions: Yale University, University of California, Los Angeles, Memorial Sloan Kettering Cancer Center, Indiana University Health, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, University of Münster, University Hospital Münster, University of Pennsylvania
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2942601937