Work

Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation

Year: 2019

Type: article

Abstract: and HRV loads in cell supernatants and BAL fluid. After pathogen infection, ST2-deficient mice showed a higher level of the host defense protein lactotransferrin in BAL fluid. Our data suggest that ST2 promotes proinflammatory responses (e.g., neutrophils) to airway bacterial and viral infection and that blocking ST2 signaling may broadly attenuate airway infection and inflammation.

Source: Infection and Immunity

DOI: 10.1128/iai.00340-19

Authors: Niccolette Schaunaman, Amelia Sanchez, Kris Genelyn Dimasuay, Nicole Pavelka, Mari Numata, Rafeul Alam, Richard J. Martin, Hong Wei Chu

Institutions: National Jewish Health, University of Colorado Denver

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Jewish Health, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: Steroid resistance of airway ILC2s, Novel function of MUC18: amplification of inflammation in allergic lungs, SPLUNC1 in Severe Asthma, IRAK-M in lung defense against rhinovirus infection, Defining Molecular Phenotypes of Exacerbation Prone Asthmatics, Sprouty-2 Regulation of Signaling in Asthma, Airway Th2Th17 Cells in Refractory Asthma, Innate Immunity and Viral Infection in Asthma

OpenAlex ID: W2942614661

FWCI: 0.698

Cites: 53

Cited by: 18

Related to: 10